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COVID’s Impact on the Fitness Industry [35+ Stats and Facts]

COVID’s Impact on the Fitness Industry [35+ Stats and Facts]

Posted on 14 January, 2021 by Nicholas Rizzo

The global pandemic is the biggest disruption the fitness industry has ever faced. To develop a greater understanding of just how the industry is being impacted and shifting, we spent hours researching, analyzing, and compiling the newest research, stats, facts, and data.

Specifically, the research compiled addresses:

  1. Gym closures and bankruptcy during the pandemic 
  2. Job loss in the fitness industry during the pandemic 
  3. Impact of COVID-19 on gym memberships
  4. Member attitudes toward returning to gyms
  5. Growth of digital and at-home fitness
  6. Investing in at-home equipment 
  7. COVID-19’s impact on exercise behavior 

For additional gym statistics, you can also see the 75+ gym membership statistics and the 200+ gym industry statistics that we researched ane compiled for 2019/2020.

Gym closures and bankruptcy during the pandemic

  • It is estimated that the US gym and health club industry lost $13.9 billion from mid-March to August 31 [IHRSA, October 2020]
  • It’s predicted that about 25% of gyms in the US will be closing by 2020 [IHRSA, October 2020]

 

  • More than 38,000 gyms and health clubs have been closed down because of the virus as of May 2020 [Harrison Co., May 2020]
  • 23.9% of US gym members report that their gym is still closed as of August 2020 [RunRepeat]
  • Gyms that filed for bankruptcy include: Cyc Fitness, YogaWorks, Flywheel Sports, Town Sports International, 24 Hour Fitness, Gold’s Gym, and Modell’s Sporting Goods [Business Insider, Oct 2020]
  • 50% of Gold’s Gym location plan to close permanently (not including franchises) and the rest hope to re-open in August [Eisneramper, 2020]
  • ClassPass Inc.’s revenue decreased by 95% in April leading the company to lay off 50% of its workforce [Eisnerramper, 2020]

Job loss in the fitness industry during the pandemic

  • Around 500,000 gym industry employees have been laid off due to COVID [Harrison Co., May 2020]
  • 58% of trainers lost some or all of their income [The Personal Trainer Development Center, 2020]
  • 1% of trainers say that they’re going to leave the fitness industry [The Personal Trainer Development Center, 2020]

 

  • 83% of trainers say that they’ll work primarily online after the pandemic [The Personal Trainer Development Center, 2020]

 

Impact of COVID-19 on gym memberships

  • 60% of Americans plan to cancel their memberships [Freeletics, July 2020]
  • 59% of Americans don’t plan to renew their gym memberships after COVID [TD Ameritrade, 2020]
  • 59.06% of gym members are considering to cancel or have canceled their memberships [Runrepeat, September 2020]

Member attitudes toward returning to gyms

  • 25% of Americans don’t plan to go back to the gym [Lifeaid, June 2020]
  • In a Morning Consult poll, only 20% of Americans are comfortable going to the gym as of July  [Morning Consult]
  • In April 2020, 68% of Americans stated that they are much less likely to go back to the gym based on what they know about COVID-19 [Statista]
  • In April 2020, 18% of Americans stated that they’re not anticipating to go back to the gym or exercise classes for the next 6 months at the very least  [Statista]

Growth of digital and at-home fitness

  • 40% of respondents exercised at home for the first time because of COVID-19 [Harrison Co., May 2020]
  • During the quarantine, 74% of Americans used at least one fitness app [Freeletics, July 2020]
  • Between Q1 and Q2 of 2020, at the start of the pandemic, home fitness app downloads grew globally by 46% [Visual Capitalist]
  • Peloton is estimated to make around $1.8 billion in sales for 2020 [Statista, September 2020]

 

  • Beachbody, the fitness company, experienced a 200% growth in subscribers since shifting to online classes [Gulfnews, March 2020]
  • Tonal, a company that offers a $3000 home workout system, reported to having tripled their sales in the third week of March [Business Insider, March 2020]

 

  • India had the highest increase of fitness app downloads at 156% as well as the largest increase in Daily Active Users with 84% more people using fitness apps each day [World Economic Forum, September 2020]
  • Daily Active Users of fitness apps in the US is the largest in the world and manage to grow by 8% in Q2 of 2020 [World Economic Forum, September 2020]

Investing in at-home equipment

  • An average of $95.79 has been invested by Americans toward at-home fitness in the last three months [Freeletics, July 2020]
  • Yoga mats, resistance bands, and dumbbells are the top fitness equipment that people invest in during the pandemic [Freeletics, July 2020]
  • 25% of Americans bought an exercise bike while 21% purchased a treadmill or elliptical [Freeletics, July 2020]
  • 60% of gym members enjoyed their home workouts to the point where they plan to cancel their gym memberships [Visual Capitalist]

COVID-19’s impact on exercise behavior

  • There’s been an 88% average increase in exercise for people who normally exercise 1-2 times per week [RunRepeat]
  • In a survey, 37% out of a thousand fitness club users state that they will work out more after COVID. Over 50% said that this is due to their “renewed appreciation for their health and well-being” [Harrison Co.]
  • 50% of Americans say that they are less active during the pandemic-related shutdowns [IHRSA, 2020]
  • 65% of respondents report that working out at home alone during the lockdown boosted their confidence [Freeletics, July 2020]
  • 60% of men said their top reason for working out during the pandemic was for their mental health [Freeletics, July 2020]
  • Reducing boredom (52%) was the top reason why women are working out during the pandemic [Freeletics, July 2020]

How COVID-19 Is Transforming The Fitness Industry

How COVID-19 Is Transforming The Fitness Industry

Jess Cording

It’s been well established that, beyond its benefit to our physical health, exercise is also good for stress management and cognitive function. However, many people have struggled to make time, especially when having to factor in a work commute and professional, family, or social obligations. The cost of gym or studio memberships has also been a common barrier to exercise.

However, when the coronavirus COVID-19 pandemic hit and at-home workouts suddenly became the norm, many who still wanted that group class experience turned to virtual wellness in the form of streaming live and pre-recorded classes.

Woman Searches Mobile App on Digital Tablet for Exercise Class

Because of the COVID-19 Pandemic, at-home workouts have become the norm.

GETTY

I spoke with Amaya Weddle, who is the Vice President of Research and Product Marketing at Mindbody, a technology platform that connects the world to wellness. “The way we define wellness at Mindbody is—it’s a broad category that operates everything from fitness studios to salons and also integrative health practitioners.” Because business owners can operate their wellness business through the platform, Mindbody has been able to analyze that data and also survey customers who use the platform to book services.

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She says, “Our research team has been doing surveys with our consumer base, and we’ve been gathering data to just keep a pulse on the industry, and we’ve leaned into studying the virtual experience.” It’s provided an opportunity to learn about how this technology is transforming the industry and making wellness a lot more accessible, she explains. Here’s what the data has shown.

Changes in the Use of Virtual Content

While virtual workouts were in existence prior to the COVID-19 pandemic, use has predictably increased. Mindbody data showed a huge jump in consumers accessing virtual content since March of 2020. 73% of consumers are using pre-recorded video versus 17% in 2019; 85% are using livestream classes weekly versus 7% in 2019.

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Changes in Workout Frequency

The data also showed that since March 2020, consumers are actually working out even more than before, with 56% of respondents exercising least five times per week. Weddle explains, “Consumers are able to just show up and have that experience in the comfort of their home. Many are reporting how great it is because it doesn’t involve a commute, so they’re finding that they’re able to squeeze in those workouts between, maybe when work ends and when they have family responsibilities, in ways that they couldn’t before.”

She adds, “We’re also hearing from a lot of consumers who maybe feel judged or embarrassed or like they have to look a certain way in class and that livestreaming gives them access to new kinds of workouts that they wanted to try” but didn’t feel comfortable joining.

She adds that, for consumers who reported that body image issues or feeling embarrassed by lack of experience had previously kept them from joining studio classes, live streaming has made them feel more comfortable trying new classes.

Closeup on laptop and woman doing abdominal crunches

Streaming workouts have made the group fitness class experience more accessible while social … [+]

GETTY

The Most Popular Workouts

Yoga has been the most popular virtual class booked on Mindbody, making up 32% of virtual bookings with an average of nearly 22,000 yoga bookings per day. Mindbody predicts yoga will continue to be popular when studios reopen because it’s very low touch and students can bring their own mats.

Following yoga, the most popular virtual bookings are High Intensity Interval Training (15.6% of virtual bookings), Pilates (8.3%) and Barre (7.9%). There has also been an increase in the booking of virtual meditation classes.

The average cost of a class is $11—about half of the average in-studio class.

Digital Fitness Is Here To Stay

46% of survey participants stated that they intend to make virtual classes a regular part of their routine, even after studios reopen. A third of consumers also stated that they plan to visit more studios after trying new workouts virtually and that 40% of consumers are booking workouts with studios they have never physically visited before, allowing businesses to reach “digital-first” clients.

To support business owners who use Mindbody, Weddle says, “We just launched our own proprietary solutions so that our customers no longer have to use video conferencing services like Zoom. We’re making a lot of investment there because we think that the industry is headed to being a lot more hybrid in the future.”

She adds, “For me, as a researcher at heart, it’s been fascinating to watch the industry transform so rapidly. We started looking at the impact of virtual fitness in 2019, when companies like Peloton and MIRROR and smart home equipment makers were coming up and creating a lot of stir. What COVID has done, I think, is that it’s accelerated a trend that was already in the making. It’s really pushed the industry forward and forced a lot of change.”

For example, business owners have had to adapt by creating their own versions of digital classes to meet consumer needs.

Weddle also highlights that, according to Mindbody’s data, many consumers still also really want an authentic community experience in addition to digital services. “One thing that excites me,” she says, is exploring, “how we can continue fostering community and how these technologies can help to strengthen those bonds and supplement what’s done in a person-to-person capacity.”

HIIT Exercises – These Are the 7 Best for Home

HIIT Exercises – These Are the 7 Best for Home

High Intensity Interval Training (HIIT) has it all. But which exercises are actually done at HIIT and which are the best? ISPO.com has compiled the top exercises with the most important background information in this article.

Sportler macht die HIIT Übung Burpee

HIIT Is a Challenge – Especially for Beginners

High Intensity Interval Training is, as the name suggests, extremely intensive. Especially for beginners this can be overly demanding. In order to avoid injuries or ineffective exercise execution, we have selected HIIT exercises that can be performed effectively and safely by beginners and advanced users alike.

HIIT can be performed with or without equipment. However, heavier weights and more complex exercises are more suitable for more advanced athletes. Therefore, we have limited our choice to exercises with your own body weight – they are safe and can be performed anywhere at any time.

Three Quality Standards for Optimal Exercise Execution

No matter which exercise we use for our fitness training, the rule is: quality before quantity. To ensure that we train effectively and safely, we must perform the exercises cleanly. Therefore the first quality standard is clean exercise performance. The exercises must be performed correctly (not perfectly) even under fatigue. This is especially important in the beginning to avoid making mistakes.

In the same way, HIIT training only works if the appropriate intensity is given. Therefore, it is important to really use the stress phases of the training! It is better to work a little slower and keep up the load time than to burn out in the first seconds.Accordingly, our second quality standard is intensity. Only those who train intensively can enjoy all the benefits of HIIT.

In the same way, however, the breaks should also be used well: During the (often short) breaks, it is important to regenerate as much as possible. A lot is happening here around breathing: if you get your breath under control as quickly as possible, you are better supplied with oxygen. The break can also be used for a quick (small) sip of water. But as soon as the next training phase begins, you should be ready to start again.The third and final quality standard is therefore intelligent use of breaks.

The Best HIIT Exercises

With the right exercises and appropriate training standards, nothing stands in the way of HIIT! In the following we explain which exercises can be used for training effectively and how to perform them correctly

Squat

The squat is an effective exercise to move both the hips and the knees, as well as strengthening the legs. Depending on the individual anatomy, the exercise can be performed in a narrower or wider stance.

Trainer macht einen Squat
The Squat is one of the most popular HIIT exercises

Starting position

We start from a hip to shoulder width stand, the shoulder blades are contractedand the stomach on tension. At the same time our toes grab the ground and the tips of your feet point slightly outwards.

Depth Position

To get into the low position we push our knees outwards and at the same timeour hips back. We keep our balance by leading our arms forward.We hold our chest high and look forward. From here we push ourselves up again by a powerful hip and leg extension.

Plank

The Plank is a classic core exercise, in which the hull is held statically against gravity.

Trainer führt Plank vor
Planks require tension in the whole body

Start position/stop position

We support ourselves with our forearms on the floor, paying attention to keeping our upper body straight by tension in our stomach and knees. We either place the elbows directly under the shoulders or as a more difficult version a small distance in front of the shoulders. Our hands remain open. As an advanced variant, it is also possible to switch between high and low planking.

End position

We put one arm after the other with the hand on the floor and press ourselves as high up as possible to get into the the high plank. Afterwards we go back into the start position. When changing we pay attention to a stable upper body. Only when this is given, we should select a higher frequency of positional shifts.

Bridge

The Bridge is a simple but effective exercise for hip extension.

Sportler zeigt die Ausführung einer Bridge
The bridge is less strenuous but still effective

Starting position

At the beginning, lie on your back and place your feet outside your hips, near your buttocks. We put the arms on the floor to the side to stabilize. It’s important to place you chin on your chest to get a straight spine.

End position

By tensing the buttocks we create a powerful hip extension, which we maintain at the upper point for about one second before we move on to the start position. But here we spend only little time and touch the floor for just a moment before we lift the hips again. When lifting the hips, keep the chin on the chest. Try not to overstretch the back.

As an alternative, the upper edge of the shoulder blades can also be placed on a raised surface.This exercise is called “Hip Thrust”. This makes the movement more demanding for the thighs.

Burpee

The Burpee is an endurance and strength exercise for the whole body. Because of the constant change of situation our heart has to do a lot of work, at the same time the jump and the push up train our arms and legs.

Sportler führt einen Burpee vor
The Burpee is one of the HIIT exercises that challenge the whole body

Starting position

We start the exercise in the push up position. The hands are under the shoulders and the body forms a straight line.

Interim position

Now we get our feet to our hands in one sentence and prepare for the jump.

Interim position

We explosively jump into and stretch our whole body. It is important to leave the ground with your feet. At the same time we try to touch the ceiling with our fingertips.

Interim position

After landing we put our hands back on the ground and jump back into the starting position. This variant of the Burpee deliberately avoids bending the arms towards the push-up: Due to the high intensity and associated fatigue, this presents an unnecessary risk of hyperextension of the lower back.

Split Squat

A strengthening exercise for the legs in which we alternately bend one leg while standing.

Trainer zeigt die Ausführung der Split Squat HIIT Übungen
The Split Squat trains similar muscles as the normal squat

Starting position

For the starting position we move into a lunge.The correct length can be easily figured out. Just stand with your legs together and “fall forward”. Use one leg to stop the fall. This automatically results in the optimal step length. At the same time we put our hands together in front of the chest and build up abdominal tension.The upper body follows the hips in the form of a slight forward tilt.A vertical position would possibly pull us into a hollow back.

Interim position

Now we bend our knee in a controlled manner and tap our back knee to the floor. We do not lower ourselves completely, so that the back knee does not carry any body weight. Additionally we have to keep up the muscle tension in our legs. Afterwards we push ourselves powerfully back up to the starting position. We should do this exercise after half of the exercise time with the other leg.

Row

The only exercise for which we need some equipment. In the simplified version, the TRX can also be replaced by a door frame, for example.

Trainer führt einen Row mit einem Schlingentrainer aus
The Row is one of the few HIIT exercises that requires equipment

Starting position

In the starting position, we make sure that you are already standing (beginner) or Lying (advanced) to build up a body tension:For this we tense the abdomen and pull the shoulder blades together.Our arms hang stretched out in the TRX or on an edge/door frame.

Interim position

Next we pull ourselves forward or upwards by powerfully bending our arms. At the same time we bring our own hands towards our ribs and push the shoulder blades together. After a short pause (about one second) we slowly return to the starting position.

Pushup

The pushup is one of the most popular exercises and ideal for HIIT. It can be carried out on any level surface.

Die Ausführung eines Pushups in drei Schritten
The necessary body tension and high intensity makes the pushup one of the best HIIT exercises

Starting position

We start with the hands under our shoulders and elbows stretched out. The stomach is tense and the knees are stretched. The body thus forms a line from the head to the feet. We must never lose this straight line during the pushup. Alternatively, beginners can place their hands on a raise to make the exercise easier. Only when this too is too heavy, we go down on our knees.

Interim position

We bring our upper body to the ground by bending our arms (the forehead is not enough). We keep the body tension especially in the abdomen. For self-control we can lift our hands briefly from the ground.

Start/end position

Now we bring ourselves back up from the intermediate position by powerfully stretching our arms. We have to make sure not to lose our abdominal tension. Otherwise we lose the straight line in the body.

Summary

High Intensity Interval Training is not part of our Top Trends 2020 for nothing: The versatile training method allows us to train both strength and endurance in a time-efficient way. With a program tailored to the individual training level, nothing stands in the way of improved fitness – not even the notorious lack of time.

The Seven Most Important Fitness Trends for the Year 2021

The Seven Most Important Fitness Trends for the Year 2021

The Corona pandemic has shaken up the fitness industry. Instead of the motto “higher, faster, further”, the future will see more health orientation, holistic offers and specialization in particular clientele such as risk groups. We present the seven most important fitness trends for the year 2021.

ISPO.com shows the fitness trends 2021.

Image credit: iStock

Fitness studios in Germany are in the middle of their second shutdown in the Corona year 2020, which has complex consequences – on the one hand, many fitness center operators fear for their existence with a cumulative loss for the industry of 460 million euros per lockdown month. On the other hand, many users (forcibly) reorient themselves and discover app and video training at home.

“The uncertainty in the industry is great. Many studios will not survive if the lockdown lasts much longer,” says Ralph Scholz. The head of the German Industry Association for Fitness and Health (DIFG) hopes that the fitness studios will be able to open again in January 2021 – that’s when most new members usually sign up with the Christmas kilos on their ribs. 

Thanks also to the representative survey “Fitness in Times of Corona”, Scholz knows that the pandemic will massively change the fitness economy. This makes it all the more important for all players to set the right course for the future. These are the most important fitness trends that ISPO.com and Scholz have identified for the year 2021.

1) Gyms Have to Meet High Hygiene Standards

Many people stay in shape during the lockdown period with running, walking, fitness exercises on their own or free digital services. Of these, a proud number of 73 percent intend to maintain this alternative training in the future. Although most fitness enthusiasts want to go back to the gym in the future, they place the condition that training is not associated with the risk of corona infection.

“The survey has shown that many people are concerned about having the highest possible standard of protection. It must therefore be in the studios’ own interest to ensure exactly that,” says Ralph Scholz in the ISPO interview. So the basic condition for studio operators in 2021 is to win back the confidence of fitness fans.

Over one million of the 11.6 million members in Germany in 2019 have quit their membership so far.

The most popular sport and fitness apps for every training goal

2) Fitness: Online Apps are Gaining in Importance

In the era of closed fitness studios, most sports and fitness fans have turned to online offers. Apps such as Freeletics, which use artificial intelligence (AI) to compile individual training offers for users, are particularly popular. “The main benefits for users are access to training planning, monitoring and even motivation at a fraction of the current cost, which means that many more people can be reached than ever before,” says Simon Alger, Lead Data Scientist at Freeletics, in an interview with ISPO.

Another example of the new digital trend: With the so-called peloton bike – a spinning bike with which you can connect with spinning fans around the world via the Internet – you can do your cardio training, for example, in virtual competition with many like-minded people around the globe.

3) Outdoor is King

The topic of outdoor fitness is gaining in importance precisely because of Corona: intensive training in particular is much less dangerous outside than indoors because of the draught. Fitness studios should therefore move more and more equipment and activities outside. This creates more safety for the users.

4) More Health Orientation in Fitness Offers

The experience of a pandemic, which is unique for everyone, has brought the topic of health into focus for many people much more than before. In principle, this is good for the fitness industry. Fitness strengthens the immune system. In fact it also needs the right and safe offers to do so.

What is needed, therefore, is the “change from a gym to a health-oriented fitness facility”, as Ralph Scholz calls it. The topics “company fitness” and “company health management” will also continue to gain in importance.

5) Differentiated and Target Group Oriented Training

Whether it’s in media use, buying behavior or travel: individualization is advancing in all areas of life. This also applies, of course, to the fitness wishes of the clientele. Whether Beer Yoga, fastest possible self-optimization through high intensity training or the new workout trend Glide Fit: differentiated and target group-oriented training is mandatory.

All-round fitness studios will continue to exist. Nevertheless boutique and micro studios with tailor-made offers are attracting more and more customers. In these difficult times, specialisation can also be financially attractive for fitness studios. Scholz: “The interesting thing is that the more special you are, the more money you can demand from customers.”

For corona risk groups and senior citizens, health and fitness are just as important as for the rest of the population. This makes seniors a core target group that must be wooed with special offers and training opportunities. This can range from individual training sessions or workouts in small training groups to special premises and digital offers for risk-free training at home.

6) Mindset: Connection of Body and Mind in Training

The trend towards topics such as yoga, mental training or Pilates already existed before Corona. But it has been intensified by the pandemic. More and more people want to combine physical training with mental relaxation.

This desire is triggered not only by job-related stress, also by the strenuous homeschooling with children or financial and health fears in connection with the pandemic. “We must therefore also strengthen the sport psychological level in our offers”, demands Ralph Scholz.

7) Sport and Fitness Merge

Rather go to the gym to train on workout devices or jog outside? For many fitness freaks this used to be a real question of faith. The Corona period, including the closure of the studios, has accelerated the resolution of this either/or situation. Many equipment fans move to alternative indoor and outdoor offers, apps included. 

“In the perception of the end consumer, this belongs together, if only because of the many new apps and wearables. That is why it is also important to develop holistic offers. In a sense, the gym is the pilot in this process,” says Scholz.

HIIT exercises: These are the 7 best ones for at home

Exercise may help reduce risk of deadly COVID-19 complication: ARDS

Exercise may help reduce risk of deadly COVID-19 complication: ARDS


Exercise has many benefits, including boosting defenses against complications that occur during SARS-CoV-2 infections. Julien McRoberts / Getty Images

Scientists are constantly revealing newly discovered benefits of exercise. In experiments over the past 10 years, my research has found that exercise can help with a respiratory problem known as ARDS.

ARDS is a type of respiratory failure characterized by rapid onset of widespread inflammation in the lungs that prevents oxygen from reaching the organs. It has been reported in many COVID-19 patients.

I am an exercise physiologist with training in medicine. More than 30 years ago, I gave up my career in general surgery in China and came to the U.S. to pursue a basic research career in molecular exercise physiology, as I was intrigued by the superb health benefits of regular exercise.

Most recently I’ve been thinking about the potential impact of regular exercise in preventing this deadly complication of COVID-19. I have not done any experiments specifically around COVID-19, but my work with mice may inform other researchers exploring ways to protect people that suffer from ARDS.

Get news that’s free, independent and based on evidence.

What is ARDS?

cause of death for 3%-17% of patients infected with SARS-CoV-2 is ARDS. COVID-19 patients with this dismal clinical complication have a mortality rate of greater than 50%.

Specifically, ARDS can occur when viral infection of the cells in the lungs activates the immune system and attracts white blood cells to travel through the bloodstream to the lung tissue to fight off the viral infection.

However, when too many white blood cells appear in the lung tissue at once, it can cause lung tissue damage. This is because they produce too much of damaging molecules called free radicals which break proteins, the cell membrane and DNA.

As a consequence, the blood vessels in the lung become leaky, causing accumulation of the fluid in the lung tissue, and the air sacs of the lung fill up with fluid. This prevents those same air sacs, called alveoli, from filling with air, blocking oxygen in the air from getting into the blood. Patients die of oxygen deprivation.

The cells that line our blood vessels are flat-shaped endothelial cells. One early step in this complicated ARDS disease process is the lining of the blood vessel becomes sticky to white blood cells by making sticky proteins on the cell surface, a phenomenon called endothelial cell activation.

This triggers a vicious cycle; the greater endothelial cell activation, the more free radicals the white blood cells release. This in turn destroys the endothelial cells, making the blood vessel leak more and damages lung tissue.

An exercise-induced antioxidant in our body

More than 10 years ago, I started to study the protective role of exercise-induced antioxidant enzymes against loss of muscle size. My research has shown that endurance exercise promotes production of an antioxidant called extracellular superoxide dismutase (EcSOD) that breaks down the free radical superoxide outside of the cells.

EcSOD is the only antioxidant enzyme that is secreted into the blood that reaches other vital organs and binds to the endothelial cells and other cells through a unique binding structure of the enzyme. This makes EcSOD unlike any supplemental antioxidant pill or food rich in antioxidants that we may consume. An oral antioxidant, once absorbed into the blood, does not target a given organ to provide protection, while EcSOD sticks to specific organs.

When I first saw the evidence of increased EcSOD in skeletal muscle by aerobic exercise training, I was inspired to do an experiment in which I tested whether just increasing the amount of this enzyme through genetic engineering, instead of naturally through exercise, would provide protection from various diseases in which free radicals are known to play important roles, such as muscle atrophy and heart failure.

EcSOD in protection against ARDS

I engineered a mouse that produced more EcSOD in skeletal muscle than would the typical mouse to mimic the effects of aerobic exercise training. We obtained clear evidence that these mice were protected from muscle atrophy and diabetes-induced heart failure.

I then artificially triggered ARDS in mice by injecting mice with a chemical produced by bacteria that are known to cause this condition. To my pleasant surprise, genetically engineered mice with higher concentrations of EcSOD in their blood were far more likely to survive the severe ARDS and multiple organ failure compared with a dismal mortality in the typical mice. This mimics the situation in intensive care where more than 80% of the patients die when they suffer from the failure of multiple organs, including ARDS.

I then confirmed that indeed it was the EcSOD in the genetically engineered mice that provided the protection. When I performed an experiment in which a genetically engineered mouse shared blood with a normal mouse following a surgical procedure called parabiosis, or I took blood from a mouse with high EcSOD and transfused it into a normal mouse suffering from ARDS, the normal mouse had reduced severity of ARDS and clinical blood markers of multiple organ failure. Using various biochemical and imaging technologies, we saw the evidence of reduced endothelial cell activation and reduced protein, cell membrane and DNA damage caused by free radicals in the lung tissue.

Learn from exercise

These studies have provided proof-of-principle evidence that delivery of the EcSOD gene or protein to elevate the amount of EcSOD in the blood and vital organs may be an effective intervention for protection of the lungs and other vital organs against damages caused by ARDS and multiple organ failure.

My findings in mice may inspire other researchers to come up with innovative ways to prevent and treat the deadly complication of COVID-19.

For example, future studies may identify the exercise type, intensity and duration to optimally increase EcSOD levels in the lungs and other vital organs in humans to build up the defense against deadly complications of COVID-19 or other disease conditions. Of course, the findings may inspire research to foster pharmacological, protein and or gene therapies to treat COVID-19 patients with ARDS.

The EcSOD antioxidant story is just one of many about the health benefits of exercise. I believe we can learn from exercise to develop effective therapies to treat ARDS caused by COVID-19 and other disease conditions.